Target Malaria publications
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A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae
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Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities
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Genomic editors for localised population suppression
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Variance partition reveals contrasting random effect contributions on the density and species composition of malaria-transmitting mosquitoes
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On the use of generative models for evolutionary inference of malaria vectors from genomic data
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Engineering drive–selection balance for localized population suppression with neutral dynamics
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Assessment of community-based resilience to malaria in two transmission settings in Western Burkina Faso
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A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae
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Unravelling the role of mitochondrial DNA in hybrid incompatibility within species of the Anopheles gambiae complex
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Procedural legitimacy: co-developing a community agreement model for genetic approaches research to malaria control in Africa
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The potential of gene drives in malaria vector species to control malaria in African environments
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Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso
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A review of applications and limitations of using aquatic macroinvertebrate predators for biocontrol of the African malaria mosquito, Anopheles gambiae sensu lato
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Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter
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Considerations for first field trials for low-threshold gene drive for malaria vector control
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The population genetics of partial diapause, with applications to the aestivating malaria mosquito Anopheles coluzzii
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Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa
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Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa: lessons learned from 10 years of Target Malaria’s work in Mali
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Male bias: Background strain and transgene insertion site
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Defining transformation events for gene drive in species complexes
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Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito
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Engagement on risk assessment for gene drive mosquitoes by EFSA and Target Malaria
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Gene drive designs for efficient and localisable population suppression using Y-linked editors
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Analysis of the Genetic Variation of the Fruitless Gene within the Anopheles gambiae (Diptera: Culicidae) Complex Populations in Africa
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Driving down malaria transmission with engineered gene drives
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Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii
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Points to consider in seeking biosafety approval for research, testing, and environmental release of experimental genetically modified biocontrol products during research and development
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A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation
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Spatial modelling of malaria prevalence associated with geographical factors in Houet province of Burkina Faso, West Africa
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Operationalizing stakeholder engagement for gene drive research in malaria elimination in Africa – translating guidance into practice
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Gene drive in species complexes: defining target organisms
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Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes
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Recommendations for environmental risk assessment of gene drive applications for malaria vector control
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A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso
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Life-history attributes of juvenile Anopheles gambiae s.s. in central Uganda; implications for malaria control interventions
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Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density
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Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes
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Articulating ethical principles guiding Target Malaria’s engagement strategy
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Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control
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Local adaptation and colonization are potential factors affecting sexual competitiveness and mating choice in Anopheles coluzzii populations
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The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes
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Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey
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Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation
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A systematic review assessing the potential for release of vector species from competition following insecticide-based population suppression of Anopheles species in Africa
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Predatory and competitive interaction in Anopheles gambiae sensu lato larval breeding habitats in selected villages of central Uganda
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Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
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Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors
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Eave and swarm collections prove effective for biased captures of male Anopheles gambiae mosquitoes in Uganda
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Contemporary Ne estimation using temporally spaced data with linked loci
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Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito
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Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control
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Addressing key gaps in implementation of mosquito larviciding to accelerate malaria vector control in southern Tanzania: results of a stakeholder engagement process in local district councils
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Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa
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Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria
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Double drives and private alleles for localised population genetic control
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A PCR-RFLP method for genotyping of inversion 2Rc in Anopheles coluzzii
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Bulk‐up synchronization of successive larval cohorts of Anopheles gambiae and Anopheles coluzzii through temperature reduction at early larval stages: effect on emergence rate, body size and mating success
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Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance
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Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating
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Co-developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting
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We need to redefine the relationship between science and its end-users
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Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods
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Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline
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Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility
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Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research
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Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso
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Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector
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A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
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Auditing Preparedness for Vector Control Field Studies
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The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication
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Modelling the potential of genetic control of malaria mosquitoes at national scale
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Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis
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Knowledge engagement in gene drive research for malaria control
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Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods
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Sustainable innovation in vector control requires strong partnerships with communities
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Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector
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A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
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Effects of the removal or reduction in density of the malaria mosquito, Anopheles gambiae s.l., on interacting predators and competitors in local ecosystems
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Target Malaria welcomes the decision of the National Biosafety Agency of Burkina Faso to approve a small-scale release of genetically modified sterile male mosquitoes
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Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso
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The African Union and international experts highlight the importance of investing in sound frameworks to enable the development of gene drive for malaria control
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Independent ecological risk assessment for a small-scale field release of a sterile male strain of Anopheles coluzzii
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Gene Drive: Evolved and Synthetic
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Gene drive to reduce malaria transmission in sub-Saharan Africa
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The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
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How driving endonuclease genes can be used to combat pests and disease vectors
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The use of sequential mark-release-recapture experiments to estimate population size, survival and dispersal of male mosquitoes of the Anopheles gambiae complex in Bana, a west African humid savannah village
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Vector control with driving Y chromosomes: modelling the evolution of resistance
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Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes
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Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing
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Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics
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Target Malaria’s response to the NAS report – Target Malaria’s statement
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Target Malaria’s response to the NAS report – Target Malaria’s response to the NAS report recommendation
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Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations
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A CRISPR-Cas9 sex-ratio distortion system for genetic control
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Gene drive through a landscape: Reaction-diffusion models of population suppression and elimination by a sex ratio distorter
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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
