Publications

Information notes

Risks & assessments 

CISRO risk assessment on male bias (Ac(PMB)1) in Burkina Faso 
Nov 2023

Development pathway 

Male bias: Background strain and transgene insertion site 
Sep 2023

Malaria 

From Aspiration to Action: What Will It Take to End Malaria? 
Sep 2020

Development pathway 

Target Malaria welcomes the decision of the National Biosafety Agency of Burkina Faso to approve a small-scale release of genetically modified sterile male mosquitoes 
Jul 2018

Technology development 

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso 
Jun 2018

Development pathway 

The African Union and international experts highlight the importance of investing in sound frameworks to enable the development of gene drive for malaria control 
Jun 2018

Risks & assessments 

Independent ecological risk assessment for a small-scale field release of a sterile male strain of Anopheles coluzzii 
May 2018

Stakeholder engagement 

Professor Austin Burt has been awarded a President’s Medal for his work engaging the public in malaria-control projects across sub-Saharan Africa 
May 2017

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s statement 
Nov 2016

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s response to the NAS report recommendation 
Nov 2016

Malaria 

Mapping the End of Malaria 
Oct 2016

Malaria 

United Nations Foundation – SDG Goal 3: Ensure healthy lives and promote well-being for all at all ages 
Mar 2016

Malaria 

United Nations Foundation – Sustainable Development Goals 
Jan 2016

Risks & assessments 

Independent risk assessment for contained laboratory studies on a sterile male strain of Anopheles gambiae 
Dec 2015

Open letters

Risks & assessments 

Research on gene drive technology can benefit conservation and public health 
Nov 2018

Development pathway 

Open Letter on Gene Drive Technology 
Dec 2016

Publications by external expert groups

Genomics & population genetics 

Potential benefits, opportunities, risks and challenges of population suppression gene drive mosquitoes for malaria control described in the scholarly literature: a rapid scoping review 
Mar 2026

Ecology 

Effects of storage conditions and digestion time on DNA amplification of biting midge (Culicoides) blood meals 
Jan 2023

Technology development 

Transgenic Insects: Techniques and Applications (2nd Edition) 
Sep 2022

Technology development 

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression 
Jun 2021

Technology development 

WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases 
May 2021

Stakeholder engagement 

Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria 
Mar 2021

Development pathway 

malERA Refresh – An updated research agenda for malaria elimination and eradication 
Jan 2018

Development pathway 

Principles for gene drive research 
Dec 2017

Genomics & population genetics 

Genetic diversity of the African malaria vector Anopheles gambiae 
Nov 2017

Risks & assessments 

Discussion paper of the Australian Academy of Science on synthetic gene drives in Australia 
May 2017

Risks & assessments 

Use of Gene Drive technology in Mosquitoes to reduce the burden of malaria in Africa: A systematic evaluation of the risks 
Dec 2016

Malaria 

United Nations Foundation – SDG Goal 3: Ensure healthy lives and promote well-being for all at all ages 
Mar 2016

Malaria 

United Nations Foundation – Sustainable Development Goals 
Jan 2016

Technology development 

Grand Challenges in Global Health: Profile of Austin Burt 
Jul 2015

Malaria 

Malaria: the last mile by Malaria Consortium 
Feb 2015

Technology development 

Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster 
May 2011

Recently published

Technology development 

A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae 
Nov 2025

Development pathway 

Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities 
Nov 2025

Entomology & insectary 

Unravelling the role of mitochondrial DNA in hybrid incompatibility within species of the Anopheles gambiae complex 
Nov 2024

Stakeholder engagement 

Procedural legitimacy: co-developing a community agreement model for genetic approaches research to malaria control in Africa 
Nov 2024

Modeling 

The potential of gene drives in malaria vector species to control malaria in African environments 
Oct 2024

Genomics & population genetics 

Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso 
Sep 2024

Ecology 

A review of applications and limitations of using aquatic macroinvertebrate predators for biocontrol of the African malaria mosquito, Anopheles gambiae sensu lato 
Jun 2024

Technology development 

Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter 
Jun 2024

Entomology & insectary 

Attributes of Anopheles gambiae swarms in South Central Uganda 
Mar 2024

Genomics & population genetics 

The population genetics of partial diapause, with applications to the aestivating malaria mosquito Anopheles coluzzii 
Mar 2024

Stakeholder engagement 

Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa: lessons learned from 10 years of Target Malaria’s work in Mali 
Jan 2024

Risks & assessments 

CISRO risk assessment on male bias (Ac(PMB)1) in Burkina Faso 
Nov 2023

Ecology 

Potential persistence mechanisms of the major Anopheles gambiae species complex malaria vectors in sub-Saharan Africa: a narrative review 
Nov 2023

Risks & assessments 

Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria 
Aug 2023

Technology development 

Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito 
May 2023

Entomology & insectary 

Considerations for Rearing and Maintaining Anopheles in the Laboratory 
May 2023

Entomology & insectary 

Anopheles Adult Anesthesia, Feeding, and Sex Separation 
May 2023

Entomology & insectary 

Anopheles Egg Collection, Disinfection, and Hatching 
May 2023

Entomology & insectary 

Anopheles Larval Rearing 
May 2023

Development pathway 

Defining transformation events for gene drive in species complexes 
Apr 2023

Stakeholder engagement 

Assessment tools for decision making for area wide malaria vector control using gene-drive approaches – perspectives on socioeconomic considerations 
Apr 2023

Malaria 

Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito 
Mar 2023

Risks & assessments 

Engagement on risk assessment for gene drive mosquitoes by EFSA and Target Malaria 
Feb 2023

Ecology 

Effects of storage conditions and digestion time on DNA amplification of biting midge (Culicoides) blood meals 
Jan 2023

Genomics & population genetics 

Gene drive designs for efficient and localisable population suppression using Y-linked editors 
Dec 2022

Malaria 

WHO World malaria report 2022 
Dec 2022

Genomics & population genetics 

Analysis of the Genetic Variation of the Fruitless Gene within the Anopheles gambiae (Diptera: Culicidae) Complex Populations in Africa 
Nov 2022

Technology development 

Driving down malaria transmission with engineered gene drives 
Oct 2022

Technology development 

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii 
Oct 2022

Risks & assessments 

Points to consider in seeking biosafety approval for research, testing, and environmental release of experimental genetically modified biocontrol products during research and development 
Oct 2022

Modeling 

A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation 
Aug 2022

Modeling 

Spatial modelling of malaria prevalence associated with geographical factors in Houet province of Burkina Faso, West Africa 
Aug 2022

Stakeholder engagement 

Operationalizing stakeholder engagement for gene drive research in malaria elimination in Africa – translating guidance into practice 
Jul 2022

Risks & assessments 

Gene drive in species complexes: defining target organisms 
Jul 2022

Technology development 

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes 
Jul 2022

Entomology & insectary 

Latitudinal and anthropogenic effects on the structuring of networks linking blood-feeding flies and their vertebrate hosts 
Jun 2022

Risks & assessments 

Recommendations for environmental risk assessment of gene drive applications for malaria vector control 
May 2022

Stakeholder engagement 

A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso 
Apr 2022

Malaria 

Life-history attributes of juvenile Anopheles gambiae s.s. in central Uganda; implications for malaria control interventions 
Apr 2022

Genomics & population genetics 

Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density 
Mar 2022

Entomology & insectary 

Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes 
Feb 2022

Stakeholder engagement 

Articulating ethical principles guiding Target Malaria’s engagement strategy 
Feb 2022

Development pathway 

Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control 
Jan 2022

Entomology & insectary 

Local adaptation and colonization are potential factors affecting sexual competitiveness and mating choice in Anopheles coluzzii populations 
Jan 2022

Malaria 

WHO World malaria report 2021 
Dec 2021

Technology development 

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression 
Jun 2021

Technology development 

WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases 
May 2021

Genomics & population genetics 

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance 
Jan 2021

Genomics & population genetics 

Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating 
Jan 2021

Stakeholder engagement 

Co-developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting 
Jan 2021

Stakeholder engagement 

We need to redefine the relationship between science and its end-users 
Dec 2020

Malaria 

WHO World malaria report 2020 
Dec 2020

Entomology & insectary 

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods 
Oct 2020

Genomics & population genetics 

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline 
Oct 2020

Modeling 

European Academies’ Science Advisory Council report on Genome Editing 
Sep 2020

Modeling 

Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility 
Aug 2020

Stakeholder engagement 

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research 
Jul 2020

Stakeholder engagement 

Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso 
Jun 2020

Technology development 

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector 
Jun 2020

Technology development 

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae 
May 2020

Entomology & insectary 

Auditing Preparedness for Vector Control Field Studies 
Apr 2020

Development pathway 

The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication 
Apr 2020

Malaria 

WHO World Malaria Report 2019 
Dec 2019

Malaria 

Rapport 2019 sur le Paludisme dans le monde 
Dec 2019

Stakeholder engagement 

Knowledge engagement in gene drive research for malaria control 
Apr 2019

Stakeholder engagement 

Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods 
Apr 2019

Stakeholder engagement 

Sustainable innovation in vector control requires strong partnerships with communities 
Apr 2019

Reports by external expert groups

Malaria 

WHO World malaria report 2022 
Dec 2022

Malaria 

WHO World malaria report 2021 
Dec 2021

Malaria 

Global Malaria Burden Map by Medicines for Malaria Venture (MMV) and the WHO Global Malaria Programme 
Jul 2021

Malaria 

WHO World malaria report 2020 
Dec 2020

Development pathway 

International experts report on the “Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group” 
Sep 2020

Malaria 

WHO World Malaria Report 2019 
Dec 2019

Malaria 

WHO World Malaria Report 2018 
Dec 2018

Risks & assessments 

Royal Society’s report on the potential uses for genetic technologies 
Sep 2018

Development pathway 

The African Union’s report on “Gene Drives for malaria control and elimination in Africa” 
Sep 2018

Development pathway 

Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group 
Jun 2018

Development pathway 

Report of the High-Level African Union Panel on Emerging Technologies (APET) on Gene Drives for Malaria Control and Elimination in Africa 
Jun 2018

Risks & assessments 

Gene editing in an international context: Scientific, economic and social issues across sectors by OECD 
Mar 2018

Malaria 

World Malaria Report 2017 
Dec 2017

Development pathway 

The African Union commits to invest in the development and regulation of gene-drive technology 
Dec 2017

Risks & assessments 

The High Council for Biotechnology (HCB) published its views on the use of genetically modified mosquitoes for vector control 
May 2017

Risks & assessments 

Genome editing: scientific opportunities, public interests and policy options in the European Union by the EASAC (the European Academies’ Science Advisory Council) 
Mar 2017

Development pathway 

The WHO Vector Control Advisory Group (VCAG) Fifth meeting report 
Nov 2016

Malaria 

WHO World Malaria Report 2016 
Nov 2016

Risks & assessments 

Genome Editing: an ethical review by Nuffield Council on Bioethics 
Sep 2016

Risks & assessments 

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values 
Jul 2016

Risks & assessments 

UK House of Lords Report on “Genetically Modified Insects” 
Dec 2015

Malaria 

United Nations – Transforming our World: The 2030 Agenda for Sustainable Development 
Dec 2015

Malaria 

From Aspiration to Action: What will it take to end malaria? 
Sep 2015

Malaria 

United Nations – Millennium Development Goals Report 2015 
Jul 2015

Malaria 

Speacial report FT Health: Combating Malaria by Financial Times 
Jul 2015

Development pathway 

WHO: Global Technical Strategy for Malaria 2016–2030 
Jun 2015

Target Malaria publications

Technology development 

A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae 
Nov 2025

Development pathway 

Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities 
Nov 2025

Genomics & population genetics 

Genomic editors for localised population suppression 
Oct 2025

Modeling 

Variance partition reveals contrasting random effect contributions on the density and species composition of malaria-transmitting mosquitoes 
Sep 2025

Genomics & population genetics 

On the use of generative models for evolutionary inference of malaria vectors from genomic data 
Jun 2025

Technology development 

Engineering drive–selection balance for localized population suppression with neutral dynamics 
Mar 2025

Malaria 

Assessment of community-based resilience to malaria in two transmission settings in Western Burkina Faso 
Mar 2025

Genomics & population genetics 

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae 
Jan 2025

Entomology & insectary 

Unravelling the role of mitochondrial DNA in hybrid incompatibility within species of the Anopheles gambiae complex 
Nov 2024

Stakeholder engagement 

Procedural legitimacy: co-developing a community agreement model for genetic approaches research to malaria control in Africa 
Nov 2024

Modeling 

The potential of gene drives in malaria vector species to control malaria in African environments 
Oct 2024

Genomics & population genetics 

Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso 
Sep 2024

Ecology 

A review of applications and limitations of using aquatic macroinvertebrate predators for biocontrol of the African malaria mosquito, Anopheles gambiae sensu lato 
Jun 2024

Technology development 

Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter 
Jun 2024

Technology development 

Considerations for first field trials for low-threshold gene drive for malaria vector control 
May 2024

Genomics & population genetics 

The population genetics of partial diapause, with applications to the aestivating malaria mosquito Anopheles coluzzii 
Mar 2024

Stakeholder engagement 

Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa 
Jan 2024

Stakeholder engagement 

Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa: lessons learned from 10 years of Target Malaria’s work in Mali 
Jan 2024

Development pathway 

Male bias: Background strain and transgene insertion site 
Sep 2023

Development pathway 

Defining transformation events for gene drive in species complexes 
Apr 2023

Malaria 

Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito 
Mar 2023

Risks & assessments 

Engagement on risk assessment for gene drive mosquitoes by EFSA and Target Malaria 
Feb 2023

Genomics & population genetics 

Gene drive designs for efficient and localisable population suppression using Y-linked editors 
Dec 2022

Genomics & population genetics 

Analysis of the Genetic Variation of the Fruitless Gene within the Anopheles gambiae (Diptera: Culicidae) Complex Populations in Africa 
Nov 2022

Technology development 

Driving down malaria transmission with engineered gene drives 
Oct 2022

Technology development 

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii 
Oct 2022

Risks & assessments 

Points to consider in seeking biosafety approval for research, testing, and environmental release of experimental genetically modified biocontrol products during research and development 
Oct 2022

Modeling 

A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation 
Aug 2022

Modeling 

Spatial modelling of malaria prevalence associated with geographical factors in Houet province of Burkina Faso, West Africa 
Aug 2022

Stakeholder engagement 

Operationalizing stakeholder engagement for gene drive research in malaria elimination in Africa – translating guidance into practice 
Jul 2022

Risks & assessments 

Gene drive in species complexes: defining target organisms 
Jul 2022

Technology development 

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes 
Jul 2022

Risks & assessments 

Recommendations for environmental risk assessment of gene drive applications for malaria vector control 
May 2022

Stakeholder engagement 

A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso 
Apr 2022

Malaria 

Life-history attributes of juvenile Anopheles gambiae s.s. in central Uganda; implications for malaria control interventions 
Apr 2022

Genomics & population genetics 

Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density 
Mar 2022

Entomology & insectary 

Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes 
Feb 2022

Stakeholder engagement 

Articulating ethical principles guiding Target Malaria’s engagement strategy 
Feb 2022

Development pathway 

Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control 
Jan 2022

Entomology & insectary 

Local adaptation and colonization are potential factors affecting sexual competitiveness and mating choice in Anopheles coluzzii populations 
Jan 2022

Genomics & population genetics 

The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes 
Dec 2021

Stakeholder engagement 

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey 
Oct 2021

Technology development 

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation 
Oct 2021

Development pathway 

A systematic review assessing the potential for release of vector species from competition following insecticide-based population suppression of Anopheles species in Africa 
Sep 2021

Entomology & insectary 

Predatory and competitive interaction in Anopheles gambiae sensu lato larval breeding habitats in selected villages of central Uganda 
Aug 2021

Technology development 

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field 
Jul 2021

Genomics & population genetics 

Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors 
May 2021

Entomology & insectary 

Eave and swarm collections prove effective for biased captures of male Anopheles gambiae mosquitoes in Uganda 
May 2021

Modeling 

Contemporary Ne estimation using temporally spaced data with linked loci 
May 2021

Technology development 

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito 
Apr 2021

Genomics & population genetics 

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control 
Mar 2021

Entomology & insectary 

Addressing key gaps in implementation of mosquito larviciding to accelerate malaria vector control in southern Tanzania: results of a stakeholder engagement process in local district councils 
Mar 2021

Development pathway 

Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa 
Mar 2021

Stakeholder engagement 

Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria 
Mar 2021

Genomics & population genetics 

Double drives and private alleles for localised population genetic control 
Mar 2021

Genomics & population genetics 

A PCR-RFLP method for genotyping of inversion 2Rc in Anopheles coluzzii 
Mar 2021

Entomology & insectary 

Bulk‐up synchronization of successive larval cohorts of Anopheles gambiae and Anopheles coluzzii through temperature reduction at early larval stages: effect on emergence rate, body size and mating success 
Feb 2021

Genomics & population genetics 

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance 
Jan 2021

Genomics & population genetics 

Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating 
Jan 2021

Stakeholder engagement 

Co-developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting 
Jan 2021

Stakeholder engagement 

We need to redefine the relationship between science and its end-users 
Dec 2020

Entomology & insectary 

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods 
Oct 2020

Genomics & population genetics 

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline 
Oct 2020

Modeling 

Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility 
Aug 2020

Stakeholder engagement 

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research 
Jul 2020

Stakeholder engagement 

Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso 
Jun 2020

Technology development 

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector 
Jun 2020

Technology development 

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae 
May 2020

Entomology & insectary 

Auditing Preparedness for Vector Control Field Studies 
Apr 2020

Development pathway 

The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication 
Apr 2020

Modeling 

Modelling the potential of genetic control of malaria mosquitoes at national scale 
May 2019

Technology development 

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis 
May 2019

Stakeholder engagement 

Knowledge engagement in gene drive research for malaria control 
Apr 2019

Stakeholder engagement 

Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods 
Apr 2019

Stakeholder engagement 

Sustainable innovation in vector control requires strong partnerships with communities 
Apr 2019

Technology development 

Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector 
Feb 2019

Technology development 

A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes 
Dec 2018

Ecology 

Effects of the removal or reduction in density of the malaria mosquito, Anopheles gambiae s.l., on interacting predators and competitors in local ecosystems 
Jul 2018

Development pathway 

Target Malaria welcomes the decision of the National Biosafety Agency of Burkina Faso to approve a small-scale release of genetically modified sterile male mosquitoes 
Jul 2018

Technology development 

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso 
Jun 2018

Development pathway 

The African Union and international experts highlight the importance of investing in sound frameworks to enable the development of gene drive for malaria control 
Jun 2018

Risks & assessments 

Independent ecological risk assessment for a small-scale field release of a sterile male strain of Anopheles coluzzii 
May 2018

Technology development 

Gene Drive: Evolved and Synthetic 
Feb 2018

Malaria 

Gene drive to reduce malaria transmission in sub-Saharan Africa 
Dec 2017

Technology development 

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito 
Oct 2017

Technology development 

How driving endonuclease genes can be used to combat pests and disease vectors 
Sep 2017

Entomology & insectary 

The use of sequential mark-release-recapture experiments to estimate population size, survival and dispersal of male mosquitoes of the Anopheles gambiae complex in Bana, a west African humid savannah village 
Aug 2017

Modeling 

Vector control with driving Y chromosomes: modelling the evolution of resistance 
Jul 2017

Technology development 

Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes 
Jul 2017

Technology development 

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing 
Apr 2017

Modeling 

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics 
Dec 2016

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s statement 
Nov 2016

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s response to the NAS report recommendation 
Nov 2016

Technology development 

Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations 
Sep 2016

Technology development 

A CRISPR-Cas9 sex-ratio distortion system for genetic control 
Aug 2016

Modeling 

Gene drive through a landscape: Reaction-diffusion models of population suppression and elimination by a sex ratio distorter 
Apr 2016

Technology development 

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae 
Jan 2016

Risks & assessments 

Independent risk assessment for contained laboratory studies on a sterile male strain of Anopheles gambiae 
Dec 2015

Technology development 

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa? 
Nov 2015

Technology development 

Professor Austin Burt talks about the Capabilities and Tradeoffs of Gene Drive Techniques at The National Academy of Sciences 
Oct 2015

Technology development 

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies 
Jul 2015

Modeling 

Estimating effective population size from temporally spaced samples with a novel, efficient maximum-likelihood algorithm 
Mar 2015

Technology development 

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster 
Feb 2015

Genomics & population genetics 

Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. 
Feb 2015

Genomics & population genetics 

Extensive introgression in a malaria vector species complex revealed by phylogenomics 
Jan 2015

Technology development 

A synthetic sex ratio distortion system in the human malaria mosquito 
Jun 2014

Modeling 

Heritable strategies for controlling insect vectors of disease 
Jun 2014

Technology development 

A synthetic sex ratio distortion system for the control of the human malaria mosquito 
Jun 2014

Technology development 

Site-specific genetic engineering of the Anopheles gambiae Y chromosome 
May 2014

Genomics & population genetics 

MegaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering 
Feb 2014

Genomics & population genetics 

Genomic Analyses of Three Malaria Vectors Reveals Extensive Shared Polymorphism but Contrasting Population Histories 
Jan 2014

Modeling 

Modelling the spatial spread of a homing endonuclease gene in a mosquito population 
Jul 2013

Modeling 

Mosquito ecology and control of malaria 
Nov 2012

Development pathway 

Lessons from Agriculture for the Sustainable Management of Malaria Vectors 
Jul 2012

Technology development 

Demasculinization of the Anopheles gambiae X chromosome 
May 2012

Modeling 

Requirements for effective malaria control with homing endonuclease genes 
Oct 2011

Technology development 

Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases 
Apr 2011

Technology development 

Tapping natural reservoirs of homing endonucleases for targeted gene modification 
Apr 2011

Technology development 

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito 
Apr 2011

Modeling 

The dominant Anopheles vectors of human malaria in Africa, Europe and the Middle East: occurrence data, distribution maps and bionomic précis 
Dec 2010

Technology development 

Developing transgenic Anopheles mosquitoes for the sterile insect technique 
Sep 2010

Technology development 

Sex separation strategies: past experience and new approaches 
Nov 2009

Technology development 

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display 
Sep 2009

Technology development 

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies 
Jul 2009

Technology development 

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae 
Dec 2008

Technology development 

Coevolution of homing endonuclease specificity and its host target sequence 
Oct 2008

Modeling 

An age-structured model to evaluate the potential of novel malaria control interventions using fungal entomopathogen sprays 
Sep 2008

Genomics & population genetics 

The population genetics of using homing endonuclease genes in vector and pest management 
Aug 2008

Technology development 

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos 
Aug 2007

Technology development 

An Anopheles transgenic sexing strain for vector control 
Oct 2005

Modeling 

Site-specific selfish genes as tools for the control and genetic engineering of natural populations 
May 2003