Liverpool School of Tropical Medicine joins the Target Malaria Consortium

I am pleased to share that our laboratory at the Liverpool School of Tropical Medicine has joined the Target Malaria consortium to extend research on gene drive technology to the vector species  Anopheles  funestus. 

Target Malaria has so far been working on the three widespread vectors of the Anopheles gambiae species complex: An. coluzzii, An. gambiae, and An. arabiensis. As members of a species complex, these three species are morphologically indistinguishable. Together, they are among the most important malaria vectors in sub-Saharan Africa. Although they are distinct species, they can occasionally inter-breed.

In addition, Anopheles funestus is a widespread vector across sub-Saharan Africa. It is more distantly related to the gambiae species complex and is not capable of hybridising with those species. An. funestus has distinct ecological characteristics and is a highly efficient vector of malaria – its species name, funestus, means “deadly”. In some areas, it is the dominant contributor to malaria transmission. Modelling indicates that achieving the full public health impact of gene drive will require trageting of An. funestus, as malaria transmission in many regions is shared between multiple vector species.

Anopheles funestus is particularly challenging to colonise and maintain in the laboratory. Our team at the Liverpool School of Tropical Medicine was among the first to demonstrate stable genetic modification of An. funestus, establishing the technical foundation required to explore gene drive approaches in this species. Through joining Target Malaria, we will extend gene drive research beyond the gambiae complex and support the development of multi-species gene drive strategies for malaria control.