Technology development | Target Malaria

Publication – March 27, 2025

Engineering drive–selection balance for localized population suppression with neutral dynamics

Publication – June 07, 2024

Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter

Publication – May 28, 2024

Considerations for first field trials for low-threshold gene drive for malaria vector control

Publication – May 26, 2023

Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito

Publication – October 16, 2022

Driving down malaria transmission with engineered gene drives

Publication – October 16, 2022

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii

Publication – September 16, 2022

Transgenic Insects: Techniques and Applications (2nd Edition)

Publication – July 01, 2022

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes

Publication – October 04, 2021

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

Publication – July 04, 2021

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

Publication – June 02, 2021

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Publication – May 19, 2021

WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases

Publication – April 01, 2021

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito

Publication – June 20, 2020

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector

Publication – May 20, 2020

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

Publication – May 20, 2019

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis

Publication – February 20, 2019

Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector

Publication – December 20, 2018

A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

Publication – June 03, 2018

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso

Publication – February 20, 2018

Gene Drive: Evolved and Synthetic

Publication – October 20, 2017

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

Publication – September 21, 2017

How driving endonuclease genes can be used to combat pests and disease vectors

Publication – July 18, 2017

Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes

Publication – April 18, 2017

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

Publication – September 18, 2016

Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations

Publication – August 18, 2016

A CRISPR-Cas9 sex-ratio distortion system for genetic control

Publication – January 18, 2016

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

Publication – November 18, 2015

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?

Publication – October 03, 2015

Professor Austin Burt talks about the Capabilities and Tradeoffs of Gene Drive Techniques at The National Academy of Sciences

Publication – July 18, 2015

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies

Publication – July 03, 2015

Grand Challenges in Global Health: Profile of Austin Burt

Publication – February 18, 2015

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

Publication – June 18, 2014

A synthetic sex ratio distortion system in the human malaria mosquito

Publication – June 18, 2014

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Publication – May 18, 2014

Site-specific genetic engineering of the Anopheles gambiae Y chromosome

Publication – November 05, 2013

Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials

Publication – May 03, 2012

Demasculinization of the Anopheles gambiae X chromosome

Publication – May 20, 2011

Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster

Publication – April 20, 2011

Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases

Publication – April 14, 2011

Tapping natural reservoirs of homing endonucleases for targeted gene modification

Publication – April 14, 2011

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Publication – September 20, 2010

Developing transgenic Anopheles mosquitoes for the sterile insect technique

Publication – November 14, 2009

Sex separation strategies: past experience and new approaches

Publication – September 14, 2009

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

Publication – July 14, 2009

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

Publication – December 14, 2008

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae

Publication – October 14, 2008

Coevolution of homing endonuclease specificity and its host target sequence

Publication – August 14, 2007

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos

Publication – October 14, 2005

An Anopheles transgenic sexing strain for vector control

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