Technology development | Target Malaria

Publication

A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae

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Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities

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Engineering drive–selection balance for localized population suppression with neutral dynamics

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Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter

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Considerations for first field trials for low-threshold gene drive for malaria vector control

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Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito

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Driving down malaria transmission with engineered gene drives

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Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii

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Transgenic Insects: Techniques and Applications (2nd Edition)

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Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes

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Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

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Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

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A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

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WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases

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Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito

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Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector

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A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

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Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis

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Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector

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A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

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Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso

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Gene Drive: Evolved and Synthetic

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The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

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How driving endonuclease genes can be used to combat pests and disease vectors

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Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes

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Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

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Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations

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A CRISPR-Cas9 sex-ratio distortion system for genetic control

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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

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Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?

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Professor Austin Burt talks about the Capabilities and Tradeoffs of Gene Drive Techniques at The National Academy of Sciences

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Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies

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Grand Challenges in Global Health: Profile of Austin Burt

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Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

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A synthetic sex ratio distortion system in the human malaria mosquito

Publication

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Publication

Site-specific genetic engineering of the Anopheles gambiae Y chromosome

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Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials

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Demasculinization of the Anopheles gambiae X chromosome

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Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster

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Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

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A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

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Developing transgenic Anopheles mosquitoes for the sterile insect technique

Publication

Sex separation strategies: past experience and new approaches

Publication

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

Publication

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

Publication

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae

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Coevolution of homing endonuclease specificity and its host target sequence

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Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos

Publication

An Anopheles transgenic sexing strain for vector control

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