Documentation

Publications récentes

Risks & assessments 

Recommendations for environmental risk assessment of gene drive applications for malaria vector control
Mai 2022

Stakeholder engagement 

A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso
Avr 2022

Malaria 

Life-history attributes of juvenile Anopheles gambiae s.s. in central Uganda; implications for malaria control interventions
Avr 2022

Paludisme 

OMS Rapport 2021 sur le paludisme dans le monde
Mar 2022

Genomics & population genetics 

Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density
Mar 2022

Entomology & insectary 

Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes
Fév 2022

Stakeholder engagement 

Articulating ethical principles guiding Target Malaria’s engagement strategy
Fév 2022

Development pathway 

Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control
Jan 2022

Entomology & insectary 

Local adaptation and colonization are potential factors affecting sexual competitiveness and mating choice in Anopheles coluzzii populations
Jan 2022

Malaria 

WHO World malaria report 2021
Déc 2021

Technology development 

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression
Juin 2021

Technology development 

WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases
Mai 2021

Développement de la technologie 

L’OMS publie de nouvelles orientations pour la recherche sur les moustiques génétiquement modifiés afin de lutter contre le paludisme et d’autres maladies à transmission vectorielle
Mai 2021

Genomics & population genetics 

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance
Jan 2021

Genomics & population genetics 

Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating
Jan 2021

Stakeholder engagement 

Co-developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting
Jan 2021

Stakeholder engagement 

We need to redefine the relationship between science and its end-users
Déc 2020

Malaria 

WHO World malaria report 2020
Déc 2020

Paludisme 

Rapport 2020 sur le Paludisme dans le monde
Déc 2020

Entomology & insectary 

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods
Oct 2020

Genomics & population genetics 

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline
Oct 2020

Modeling 

European Academies’ Science Advisory Council report on Genome Editing
Sep 2020

Modeling 

Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility
Août 2020

Stakeholder engagement 

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research
Juil 2020

Stakeholder engagement 

Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso
Juin 2020

Technology development 

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector
Juin 2020

Technology development 

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Mai 2020

Entomology & insectary 

Auditing Preparedness for Vector Control Field Studies
Avr 2020

Development pathway 

The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication
Avr 2020

Malaria 

WHO World Malaria Report 2019
Déc 2019

Stakeholder engagement 

Knowledge engagement in gene drive research for malaria control
Avr 2019

Stakeholder engagement 

Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods
Avr 2019

Stakeholder engagement 

Sustainable innovation in vector control requires strong partnerships with communities
Avr 2019

Publications Target Malaria

Risks & assessments 

Recommendations for environmental risk assessment of gene drive applications for malaria vector control
Mai 2022

Stakeholder engagement 

A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso
Avr 2022

Malaria 

Life-history attributes of juvenile Anopheles gambiae s.s. in central Uganda; implications for malaria control interventions
Avr 2022

Genomics & population genetics 

Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density
Mar 2022

Entomology & insectary 

Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes
Fév 2022

Stakeholder engagement 

Articulating ethical principles guiding Target Malaria’s engagement strategy
Fév 2022

Development pathway 

Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control
Jan 2022

Entomology & insectary 

Local adaptation and colonization are potential factors affecting sexual competitiveness and mating choice in Anopheles coluzzii populations
Jan 2022

Genomics & population genetics 

The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes
Déc 2021

Stakeholder engagement 

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey
Oct 2021

Technology development 

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation
Oct 2021

Development pathway 

A systematic review assessing the potential for release of vector species from competition following insecticide-based population suppression of Anopheles species in Africa
Sep 2021

Technology development 

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
Juil 2021

Genomics & population genetics 

Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors
Mai 2021

Entomology & insectary 

Eave and swarm collections prove effective for biased captures of male Anopheles gambiae mosquitoes in Uganda
Mai 2021

Modeling 

Contemporary Ne estimation using temporally spaced data with linked loci
Mai 2021

Technology development 

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito
Avr 2021

Genomics & population genetics 

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control
Mar 2021

Development pathway 

Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa
Mar 2021

Stakeholder engagement 

Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria
Mar 2021

Genomics & population genetics 

Double drives and private alleles for localised population genetic control
Mar 2021

Genomics & population genetics 

A PCR-RFLP method for genotyping of inversion 2Rc in Anopheles coluzzii
Mar 2021

Genomics & population genetics 

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance
Jan 2021

Genomics & population genetics 

Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating
Jan 2021

Stakeholder engagement 

Co-developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting
Jan 2021

Stakeholder engagement 

We need to redefine the relationship between science and its end-users
Déc 2020

Entomology & insectary 

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods
Oct 2020

Genomics & population genetics 

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline
Oct 2020

Modeling 

Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility
Août 2020

Stakeholder engagement 

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research
Juil 2020

Stakeholder engagement 

Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso
Juin 2020

Technology development 

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector
Juin 2020

Technology development 

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Mai 2020

Entomology & insectary 

Auditing Preparedness for Vector Control Field Studies
Avr 2020

Development pathway 

The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication
Avr 2020

Modeling 

Modelling the potential of genetic control of malaria mosquitoes at national scale
Mai 2019

Technology development 

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis
Mai 2019

Stakeholder engagement 

Knowledge engagement in gene drive research for malaria control
Avr 2019

Stakeholder engagement 

Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods
Avr 2019

Stakeholder engagement 

Sustainable innovation in vector control requires strong partnerships with communities
Avr 2019

Technology development 

Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector
Fév 2019

Technology development 

A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
Déc 2018

Ecology 

Effects of the removal or reduction in density of the malaria mosquito, Anopheles gambiae s.l., on interacting predators and competitors in local ecosystems
Juil 2018

Development pathway 

Target Malaria welcomes the decision of the National Biosafety Agency of Burkina Faso to approve a small-scale release of genetically modified sterile male mosquitoes
Juil 2018

Parcours de développement 

Target Malaria se félicite de l’obtention de l’autorisation de l’Agence Nationale de Biosécurité du Burkina Faso pour procéder à un lâcher à petite échelle de moustiques mâles stériles génétiquement modifiés
Juil 2018

Technology development 

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso
Juin 2018

Development pathway 

The African Union and international experts highlight the importance of investing in sound frameworks to enable the development of gene drive for malaria control
Juin 2018

Risks & assessments 

Independent ecological risk assessment for a small-scale field release of a sterile male strain of Anopheles coluzzii
Mai 2018

Risques et évaluations 

Évaluation indépendante du risque écologique lié au lâcher à petite échelle d’une souche mâle stérile Anopheles coluzzii
Mai 2018

Technology development 

Gene Drive: Evolved and Synthetic
Fév 2018

Malaria 

Gene drive to reduce malaria transmission in sub-Saharan Africa
Déc 2017

Technology development 

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
Oct 2017

Technology development 

How driving endonuclease genes can be used to combat pests and disease vectors
Sep 2017

Entomology & insectary 

The use of sequential mark-release-recapture experiments to estimate population size, survival and dispersal of male mosquitoes of the Anopheles gambiae complex in Bana, a west African humid savannah village
Août 2017

Modeling 

Vector control with driving Y chromosomes: modelling the evolution of resistance
Juil 2017

Technology development 

Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes
Juil 2017

Technology development 

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing
Avr 2017

Modeling 

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics
Déc 2016

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s statement
Nov 2016

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s response to the NAS report recommendation
Nov 2016

Technology development 

Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations
Sep 2016

Technology development 

A CRISPR-Cas9 sex-ratio distortion system for genetic control
Août 2016

Modeling 

Gene drive through a landscape: Reaction-diffusion models of population suppression and elimination by a sex ratio distorter
Avr 2016

Technology development 

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
Jan 2016

Risks & assessments 

Independent risk assessment for contained laboratory studies on a sterile male strain of Anopheles gambiae
Déc 2015

Technology development 

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?
Nov 2015

Technology development 

Professor Austin Burt talks about the Capabilities and Tradeoffs of Gene Drive Techniques at The National Academy of Sciences
Oct 2015

Technology development 

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies
Juil 2015

Modeling 

Estimating effective population size from temporally spaced samples with a novel, efficient maximum-likelihood algorithm
Mar 2015

Technology development 

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster
Fév 2015

Genomics & population genetics 

Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
Fév 2015

Genomics & population genetics 

Extensive introgression in a malaria vector species complex revealed by phylogenomics
Jan 2015

Technology development 

A synthetic sex ratio distortion system in the human malaria mosquito
Juin 2014

Modeling 

Heritable strategies for controlling insect vectors of disease
Juin 2014

Technology development 

A synthetic sex ratio distortion system for the control of the human malaria mosquito
Juin 2014

Technology development 

Site-specific genetic engineering of the Anopheles gambiae Y chromosome
Mai 2014

Genomics & population genetics 

MegaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
Fév 2014

Genomics & population genetics 

Genomic Analyses of Three Malaria Vectors Reveals Extensive Shared Polymorphism but Contrasting Population Histories
Jan 2014

Modeling 

Modelling the spatial spread of a homing endonuclease gene in a mosquito population
Juil 2013

Modeling 

Mosquito ecology and control of malaria
Nov 2012

Development pathway 

Lessons from Agriculture for the Sustainable Management of Malaria Vectors
Juil 2012

Technology development 

Demasculinization of the Anopheles gambiae X chromosome
Mai 2012

Modeling 

Requirements for effective malaria control with homing endonuclease genes
Oct 2011

Technology development 

Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases
Avr 2011

Technology development 

Tapping natural reservoirs of homing endonucleases for targeted gene modification
Avr 2011

Technology development 

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
Avr 2011

Modeling 

The dominant Anopheles vectors of human malaria in Africa, Europe and the Middle East: occurrence data, distribution maps and bionomic précis
Déc 2010

Technology development 

Developing transgenic Anopheles mosquitoes for the sterile insect technique
Sep 2010

Technology development 

Sex separation strategies: past experience and new approaches
Nov 2009

Technology development 

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display
Sep 2009

Technology development 

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies
Juil 2009

Technology development 

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae
Déc 2008

Technology development 

Coevolution of homing endonuclease specificity and its host target sequence
Oct 2008

Modeling 

An age-structured model to evaluate the potential of novel malaria control interventions using fungal entomopathogen sprays
Sep 2008

Genomics & population genetics 

The population genetics of using homing endonuclease genes in vector and pest management
Août 2008

Technology development 

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos
Août 2007

Technology development 

An Anopheles transgenic sexing strain for vector control
Oct 2005

Modeling 

Site-specific selfish genes as tools for the control and genetic engineering of natural populations
Mai 2003

Publications de groupes d'experts externes

Technology development 

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression
Juin 2021

Technology development 

WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases
Mai 2021

Développement de la technologie 

L’OMS publie de nouvelles orientations pour la recherche sur les moustiques génétiquement modifiés afin de lutter contre le paludisme et d’autres maladies à transmission vectorielle
Mai 2021

Stakeholder engagement 

Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria
Mar 2021

Development pathway 

malERA Refresh – An updated research agenda for malaria elimination and eradication
Jan 2018

Development pathway 

Principles for gene drive research
Déc 2017

Genomics & population genetics 

Genetic diversity of the African malaria vector Anopheles gambiae
Nov 2017

Risks & assessments 

Discussion paper of the Australian Academy of Science on synthetic gene drives in Australia
Mai 2017

Risks & assessments 

Use of Gene Drive technology in Mosquitoes to reduce the burden of malaria in Africa: A systematic evaluation of the risks
Déc 2016

Malaria 

United Nations Foundation – SDG Goal 3: Ensure healthy lives and promote well-being for all at all ages
Mar 2016

Malaria 

United Nations Foundation – Sustainable Development Goals
Jan 2016

Paludisme 

Rapport de l’OMS sur le paludisme dans le monde 2015
Déc 2015

Technology development 

Grand Challenges in Global Health: Profile of Austin Burt
Juil 2015

Malaria 

Malaria: the last mile by Malaria Consortium
Fév 2015

Technology development 

Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster
Mai 2011

Rapports de groupes d'experts externes

Paludisme 

OMS Rapport 2021 sur le paludisme dans le monde
Mar 2022

Malaria 

WHO World malaria report 2021
Déc 2021

Parcours de développement 

La technologie « Gene Drive » pour la lutte contre le paludisme et son élimination en Afrique, l’Union Africaine s’engage
Juil 2021

Malaria 

Global Malaria Burden Map by Medicines for Malaria Venture (MMV) and the WHO Global Malaria Programme
Juil 2021

Malaria 

WHO World malaria report 2020
Déc 2020

Paludisme 

Rapport 2020 sur le Paludisme dans le monde
Déc 2020

Malaria 

WHO World Malaria Report 2019
Déc 2019

Paludisme 

Rapport 2019 sur le Paludisme dans le monde
Déc 2019

Malaria 

WHO World Malaria Report 2018
Déc 2018

Paludisme 

Rapport 2018 sur le paludisme dans le monde
Déc 2018

Risks & assessments 

Royal Society’s report on the potential uses for genetic technologies
Sep 2018

Development pathway 

The African Union’s report on “Gene Drives for malaria control and elimination in Africa”
Sep 2018

Development pathway 

Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group
Juin 2018

Parcours de développement 

La technologie « GENE DRIVE » – pour la lute contre la paludisme et son elimination en Afrique
Juin 2018

Development pathway 

Report of the High-Level African Union Panel on Emerging Technologies (APET) on Gene Drives for Malaria Control and Elimination in Africa
Juin 2018

Risks & assessments 

Gene editing in an international context: Scientific, economic and social issues across sectors by OECD
Mar 2018

Malaria 

World Malaria Report 2017
Déc 2017

Paludisme 

Rapport 2017 sur le paludisme dans le monde
Déc 2017

Development pathway 

The African Union commits to invest in the development and regulation of gene-drive technology
Déc 2017

Risques et évaluations 

Le Haut Conseil des biotechnologies (HCB) a publié son avis concernant l’utilisation de moustiques génétiquement modifiés dans le cadre de la lutte antivectorielle
Mai 2017

Risks & assessments 

The High Council for Biotechnology (HCB) published its views on the use of genetically modified mosquitoes for vector control
Mai 2017

Risks & assessments 

Genome editing: scientific opportunities, public interests and policy options in the European Union by the EASAC (the European Academies’ Science Advisory Council)
Mar 2017

Development pathway 

The WHO Vector Control Advisory Group (VCAG) Fifth meeting report
Nov 2016

Malaria 

WHO World Malaria Report 2016
Nov 2016

Risks & assessments 

Genome Editing: an ethical review by Nuffield Council on Bioethics
Sep 2016

Risks & assessments 

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values
Juil 2016

Risks & assessments 

UK House of Lords Report on “Genetically Modified Insects”
Déc 2015

Malaria 

United Nations – Transforming our World: The 2030 Agenda for Sustainable Development
Déc 2015

Parcours de développement 

OMS: Stratégie technique mondiale de lutte contre le paludisme 2016-2030
Sep 2015

Malaria 

From Aspiration to Action: What will it take to end malaria?
Sep 2015

Malaria 

United Nations – Millennium Development Goals Report 2015
Juil 2015

Malaria 

Speacial report FT Health: Combating Malaria by Financial Times
Juil 2015

Development pathway 

WHO: Global Technical Strategy for Malaria 2016–2030
Juin 2015

Notes d'information

Development pathway 

Target Malaria welcomes the decision of the National Biosafety Agency of Burkina Faso to approve a small-scale release of genetically modified sterile male mosquitoes
Juil 2018

Parcours de développement 

Target Malaria se félicite de l’obtention de l’autorisation de l’Agence Nationale de Biosécurité du Burkina Faso pour procéder à un lâcher à petite échelle de moustiques mâles stériles génétiquement modifiés
Juil 2018

Technology development 

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso
Juin 2018

Development pathway 

The African Union and international experts highlight the importance of investing in sound frameworks to enable the development of gene drive for malaria control
Juin 2018

Risks & assessments 

Independent ecological risk assessment for a small-scale field release of a sterile male strain of Anopheles coluzzii
Mai 2018

Risques et évaluations 

Évaluation indépendante du risque écologique lié au lâcher à petite échelle d’une souche mâle stérile Anopheles coluzzii
Mai 2018

Stakeholder engagement 

Professor Austin Burt has been awarded a President’s Medal for his work engaging the public in malaria-control projects across sub-Saharan Africa
Mai 2017

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s statement
Nov 2016

Risks & assessments 

Target Malaria’s response to the NAS report – Target Malaria’s response to the NAS report recommendation
Nov 2016

Malaria 

Mapping the End of Malaria
Oct 2016

Malaria 

United Nations Foundation – SDG Goal 3: Ensure healthy lives and promote well-being for all at all ages
Mar 2016

Malaria 

United Nations Foundation – Sustainable Development Goals
Jan 2016

Risks & assessments 

Independent risk assessment for contained laboratory studies on a sterile male strain of Anopheles gambiae
Déc 2015