Développement de la technologie

Considerations for first field trials for low-threshold gene drive for malaria vector control

Posted 28th mai 2024

Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito

Posted 26th mai 2023

Driving down malaria transmission with engineered gene drives

Posted 16th octobre 2022

Garrood WT, Cuber P, Willis K, Bernardini F, Page NM, Haghighat-Khah RE. Driving down malaria transmission with engineered gene drives. Front Genet. 2022 Oct 19;13:891218. doi: 10.3389/fgene.2022.891218

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii

Posted 16th octobre 2022

 Pollegioni P, Persampieri T, Minuz RL, Bucci A, Trusso A, Di Martino S, Leo C, Bruttini M, Ciolfi M, Waldvogel AM, Tripet F, Simoni A, Crisanti A, Müller R.…

Transgenic Insects: Techniques and Applications (2nd Edition)

Posted 16th septembre 2022

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes

Posted 1st juillet 2022

Matteo Vitale, Chiara Leo, Thomas Courty, Nace Kranjc, John B. Connolly, Giulia Morselli, Christopher Bamikole, Roya Elaine Haghighat-Khah, Federica Bernardini & Silke Fuchs (2022) Comprehensive characterization of a transgene insertion…

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

Posted 4th octobre 2021

Silke Fuchs, William T. Garrood, Anna Beber, Andrew Hammond, Roberto Galizi, Matthew Gribble, Giulia Morselli, Tin-Yu J. Hui, Katie Willis, Austin Burt, Tony Nolan and Andrea Crisanti. Resistance to a…

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

Posted 4th juillet 2021

Hammond A, Pollegioni P, Persampieri T, North A, Minuz R, Trusso A, Bucci A, Kyrou K, Morianou I, Simoni A, Nolan T, Müller R, Crisanti A. Gene-drive suppression of mosquito…

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Posted 2nd juin 2021

Chrysanthi Taxiarchi

L’OMS publie de nouvelles orientations pour la recherche sur les moustiques génétiquement modifiés afin de lutter contre le paludisme et d’autres maladies à transmission vectorielle

Posted 3rd mai 2021

L’OMS publie de nouvelles orientations pour la recherche sur les moustiques génétiquement modifiés afin de lutter contre le paludisme et d’autres maladies à transmission vectorielle

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito

Posted 1st avril 2021

Garrood WT, Kranjc N, Petri K, Kim DY, Guo JA, Hammond AM, Morianou I, Pattanayak V, Joung JK, Crisanti A, Simoni A. Analysis of off-target effects in CRISPR-based gene drives…

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector

Posted 20th juin 2020

Pollegioni P, North A, Persampieri T, Bucci A, Minuz R, Groneberg DA, Nolan T, Papathanos P, Crisanti A, Muller R. Detecting the population dynamics of an autosomal sex-ratio distorter in…

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

Posted 20th mai 2020

Simoni A, Hammond AM, Beaghton AK, Galizi R, Taxiarchi C, Kyrou K, Meacci D, Gribble M, Morselli G, Burt A, Nolan T, Crisanti A. A male-biased sex distorter gene drive…

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis

Posted 20th mai 2019

Bernardini F, Kriezis A, Galizi R, Nolan T, Crisanti A. Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis. Sci Rep. 2019 Mar 26;9(1):5158. doi:…

Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector

Posted 20th février 2019

Facchinelli L, North AR, Collins CM, Menichelli M, Persampieri T, Bucci A, Spaccapelo R, Crisanti A, Benedict MQ. Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an…

A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

Posted 20th décembre 2018

Kyrou K, Hammond AM, Galizi R, Kranjc N, Burt A, Beaghton AK, Nolan T, Crisanti A. A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae…

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso

Posted 3rd juin 2018

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso

Gene Drive: Evolved and Synthetic

Posted 20th février 2018

Burt A, Crisanti A. Gene Drive: Evolved and Synthetic. ACS Chem Biol. 2018 Feb 16;13(2):343-346. doi: 10.1021/acschembio.7b01031. Epub 2018 Feb 5.

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

Posted 20th octobre 2017

Hammond AM, Kyrou K, Bruttini M, North A, Galizi R, Karlsson X, Kranjc N, Carpi FM, D’Aurizio R, Crisanti A, Nolan T. The creation and selection of mutations resistant to…

How driving endonuclease genes can be used to combat pests and disease vectors

Posted 21st septembre 2017

Godfray HCJ, North A, Burt A. How driving endonuclease genes can be used to combat pests and disease vectors. BMC Biol. 2017 Sep 11;15(1):81. doi: 10.1186/s12915-017-0420-4.

Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes

Posted 18th juillet 2017

Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

Posted 18th avril 2017

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations

Posted 18th septembre 2016

Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations

A CRISPR-Cas9 sex-ratio distortion system for genetic control

Posted 18th août 2016

A CRISPR-Cas9 sex-ratio distortion system for genetic control

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

Posted 18th janvier 2016

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?

Posted 18th novembre 2015

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?

Professor Austin Burt talks about the Capabilities and Tradeoffs of Gene Drive Techniques at The National Academy of Sciences

Posted 3rd octobre 2015

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies

Posted 18th juillet 2015

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies

Grand Challenges in Global Health: Profile of Austin Burt

Posted 3rd juillet 2015

Grand Challenges in Global Health: Profile of Austin Burt

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

Posted 18th février 2015

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

A synthetic sex ratio distortion system in the human malaria mosquito

Posted 18th juin 2014

A synthetic sex ratio distortion system in the human malaria mosquito

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Posted 18th juin 2014

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Site-specific genetic engineering of the Anopheles gambiae Y chromosome

Posted 18th mai 2014

Site-specific genetic engineering of the Anopheles gambiae Y chromosome

Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials

Posted 5th novembre 2013

Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials. T A Klein 1 , N Windbichler, A Deredec, A Burt, M Q Benedict

Demasculinization of the Anopheles gambiae X chromosome

Posted 3rd mai 2012

Demasculinization of the Anopheles gambiae X chromosome

Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster

Posted 20th mai 2011

Chan YS, Naujoks DA, Huen DS, Russell S « Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster » Genetics 188(1):33-44

Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases

Posted 20th avril 2011

Hancock PA, Sinkins SP, Godfray HCJ « Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases » PLoS Neglected Tropical Diseases 5(4):e1024

Tapping natural reservoirs of homing endonucleases for targeted gene modification

Posted 14th avril 2011

Tapping natural reservoirs of homing endonucleases for targeted gene modification

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Posted 14th avril 2011

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Developing transgenic Anopheles mosquitoes for the sterile insect technique

Posted 20th septembre 2010

Nolan T, Papathanos P, Windbichler N, Magnusson K, Benton J, Catteruccia F, Crisanti A « Developing transgenic Anopheles mosquitoes for the sterile insect technique » Genetica 139(1):33-9

Sex separation strategies: past experience and new approaches

Posted 14th novembre 2009

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

Posted 14th septembre 2009

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

Posted 14th juillet 2009

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae

Posted 14th décembre 2008

Windbichler N, Papathanos PA, Crisanti A. « Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae » PLoS Genet. 4(12):e1000291

Coevolution of homing endonuclease specificity and its host target sequence

Posted 14th octobre 2008

Scalley-Kim M, McConnell-Smith A, Stoddard BL « Coevolution of homing endonuclease specificity and its host target sequence » J. Mol. Biol. 372 (5): 1305 – 1319

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos

Posted 14th août 2007

Windbichler N, Papathanos PA, Catteruccia F, Ranson H, Burt A, Crisanti A. « Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos » Nucleic Acids Research 35(17):5922-33

An Anopheles transgenic sexing strain for vector control

Posted 14th octobre 2005

Catteruccia F, Benton JP, Crisanti A « An Anopheles transgenic sexing strain for vector control » Nature Biotechnology (2005) 23, 1414 – 1417

Développement de la technologie

Considerations for first field trials for low-threshold gene drive for malaria vector control

Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito

Driving down malaria transmission with engineered gene drives

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii

Transgenic Insects: Techniques and Applications (2nd Edition)

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

L’OMS publie de nouvelles orientations pour la recherche sur les moustiques génétiquement modifiés afin de lutter contre le paludisme et d’autres maladies à transmission vectorielle

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito

Detecting the population dynamics of an autosomal sex-ratio distorter in a malaria vector

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis

Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector

A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

Summary information note regarding the small-scale release of genetically modified sterile male mosquitoes Anopheles coluzzii strain Ac (DSM)2 in Bana village in Burkina Faso

Gene Drive: Evolved and Synthetic

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

How driving endonuclease genes can be used to combat pests and disease vectors

Rapid evolution of female-biased genes among four species of Anopheles malaria mosquitoes

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations

A CRISPR-Cas9 sex-ratio distortion system for genetic control

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?

Professor Austin Burt talks about the Capabilities and Tradeoffs of Gene Drive Techniques at The National Academy of Sciences

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies

Grand Challenges in Global Health: Profile of Austin Burt

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

A synthetic sex ratio distortion system in the human malaria mosquito

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Site-specific genetic engineering of the Anopheles gambiae Y chromosome

Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials

Demasculinization of the Anopheles gambiae X chromosome

Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster

Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases

Tapping natural reservoirs of homing endonucleases for targeted gene modification

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Developing transgenic Anopheles mosquitoes for the sterile insect technique

Sex separation strategies: past experience and new approaches

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae

Coevolution of homing endonuclease specificity and its host target sequence

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos

An Anopheles transgenic sexing strain for vector control

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