{"id":8499,"date":"2022-10-05T15:25:04","date_gmt":"2022-10-05T14:25:04","guid":{"rendered":"https:\/\/targetmalaria.org\/antimalaria-drug-resistance-an-endless-run\/"},"modified":"2023-08-14T15:32:27","modified_gmt":"2023-08-14T14:32:27","slug":"antimalaria-drug-resistance-an-endless-run","status":"publish","type":"post","link":"https:\/\/targetmalaria.org\/fr\/latest\/blog\/antimalaria-drug-resistance-an-endless-run\/","title":{"rendered":"R\u00e9sistance aux m\u00e9dicaments antipaludiques : une course sans fin"},"content":{"rendered":"\n

La r\u00e9cente publication<\/a> des r\u00e9sultats prometteurs d’un vaccin antipaludique (R21\/Matrix-M) montrant une bonne efficacit\u00e9<\/a> (78% de protection) apr\u00e8s un essai clinique de phase 2b a \u00e9t\u00e9 chaleureusement accueillie par la communaut\u00e9 scientifique, ainsi que les communaut\u00e9s menac\u00e9es.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Le paludisme est une maladie \u00e9vitable qui reste mortelle avec plus de 600 000 d\u00e9c\u00e8s annuels, dont 96% ont lieu en Afrique parmi des enfants de moins de cinq ans. Pendant tr\u00e8s longtemps, les traitements reposaient presque exclusivement sur les m\u00e9dicaments antipaludiques. En raison de la capacit\u00e9 du parasite plasmodium<\/em> \u00e0 s’adapter aux m\u00e9dicaments, les scientifiques se sont lanc\u00e9s dans une course permanente pour garder une longueur d’avance sur le parasite.<\/p>\n\n\n\n

Pendant longtemps, la chloroquine<\/strong> a \u00e9t\u00e9 le principal m\u00e9dicament antipaludique mais depuis l’apparition de souches r\u00e9sistantes \u00e0 la chloroquine dans les ann\u00e9es 1950, la r\u00e9sistance s’est propag\u00e9e rapidement entra\u00eenant une baisse d’efficacit\u00e9 et d’utilisation.<\/p>\n\n\n\n

L’art\u00e9misinine<\/strong> est d\u00e9sormais la premi\u00e8re ligne de traitement. Ce compos\u00e9 est d\u00e9riv\u00e9 d’une plante (artemisia annua<\/em>) et a valu \u00e0 son d\u00e9couvreur (Professeure Tu Youyou<\/a>) le prix Nobel de m\u00e9decine en 2015. Ce m\u00e9dicament est souvent utilis\u00e9 en association avec d’autres m\u00e9dicaments (l’art\u00e9sunate, la sulfadoxine) car il est rapidement \u00e9limin\u00e9 par le corps. Il peut ainsi tuer les parasites \u00e0 un rythme rapide avant qu’un autre m\u00e9dicament de longue dur\u00e9e ne mette fin au processus. Ces combinaisons sont connues sous le nom de th\u00e9rapies combin\u00e9es \u00e0 base d’art\u00e9misinine <\/strong>(TCA). Jusqu’\u00e0 pr\u00e9sent, cinq d’entre elles sont en service. Cette forme de m\u00e9dicament est pr\u00e9f\u00e9r\u00e9e \u00e0 l’utilisation de l’art\u00e9misinine seule pour \u00e9viter le d\u00e9veloppement de r\u00e9sistances.<\/p>\n\n\n\n

Malheureusement, des premiers signalements de r\u00e9sistance \u00e0 l’art\u00e9misinine ont \u00e9t\u00e9 d\u00e9crits en Asie du Sud en 2018. Si le m\u00e9canisme n’est pas encore enti\u00e8rement compris, une mutation du g\u00e8ne plasmodium<\/em> Kelch 13 semble \u00eatre fortement corr\u00e9l\u00e9e \u00e0 cette r\u00e9sistance.<\/p>\n\n\n\n

La pr\u00e9sence de souches r\u00e9sistantes \u00e0 l’art\u00e9misinine en Afrique fait encore d\u00e9bat. Des rapports font \u00e9tat de sa pr\u00e9sence en Ouganda. Notamment, l’art\u00e9misinine \u00e9limine toujours le parasite mais \u00e0 un rythme plus lent qu’il ne devrait l’\u00eatre, ouvrant la voie \u00e0 une future r\u00e9sistance.<\/p>\n\n\n\n

L’apparition de cette r\u00e9sistance a longtemps \u00e9t\u00e9 redout\u00e9e et la communaut\u00e9 scientifique travaillait d\u00e9j\u00e0 sur des TCA suppl\u00e9mentaires (actuellement cinq sont en d\u00e9veloppement). D’autres programmes de d\u00e9veloppement de m\u00e9dicaments antipaludiques sont en cours. N\u00e9anmoins, la route est encore longue pour obtenir le prochain m\u00e9dicament qui remplacera l’art\u00e9misinine et ses d\u00e9riv\u00e9s comme traitement de premi\u00e8re ligne.<\/p>\n\n\n\n

Ce ph\u00e9nom\u00e8ne de r\u00e9sistance met en \u00e9vidence le fait que pour lutter contre le paludisme, une approche multifactorielle est n\u00e9cessaire. Le d\u00e9veloppement de vaccins, les traitements m\u00e9dicamenteux et les strat\u00e9gies de lutte antivectorielle sont des solutions compl\u00e9mentaires \u00e0 un m\u00eame probl\u00e8me : combattre et en finir avec le paludisme.<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

La r\u00e9cente publication des r\u00e9sultats prometteurs d’un vaccin antipaludique (R21\/Matrix-M) montrant une bonne efficacit\u00e9 (78% de protection) apr\u00e8s un essai clinique de phase 2b a \u00e9t\u00e9 chaleureusement accueillie par la communaut\u00e9 scientifique, ainsi que les communaut\u00e9s menac\u00e9es. Le paludisme est une maladie \u00e9vitable qui reste mortelle avec plus de 600 000 d\u00e9c\u00e8s annuels, dont 96% […]<\/p>\n","protected":false},"author":32,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","featured_image_focal_point":[],"_image_focal_point":[],"footnotes":""},"categories":[113],"profile_tax":[],"class_list":["post-8499","post","type-post","status-publish","format-standard","hentry","category-blog","post_writers-florian-noulin","post_writers-florian-noulin-fr"],"acf":[],"yoast_head":"\nR\u00e9sistance aux m\u00e9dicaments antipaludiques : une course sans fin - Target Malaria<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/targetmalaria.org\/fr\/latest\/blog\/antimalaria-drug-resistance-an-endless-run\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R\u00e9sistance aux m\u00e9dicaments antipaludiques : une course sans fin - Target Malaria\" \/>\n<meta property=\"og:description\" content=\"La r\u00e9cente publication des r\u00e9sultats prometteurs d’un vaccin antipaludique (R21\/Matrix-M) montrant une bonne efficacit\u00e9 (78% de protection) apr\u00e8s un essai clinique de phase 2b a \u00e9t\u00e9 chaleureusement accueillie par la communaut\u00e9 scientifique, ainsi que les communaut\u00e9s menac\u00e9es. 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