{"id":5199,"date":"2021-04-27T12:31:32","date_gmt":"2021-04-27T11:31:32","guid":{"rendered":"https:\/\/targetmalaria.org\/?page_id=5199"},"modified":"2025-11-17T14:45:30","modified_gmt":"2025-11-17T14:45:30","slug":"male-sterile-genetiquement-modifie","status":"publish","type":"page","link":"https:\/\/targetmalaria.org\/fr\/notre-mission\/notre-processus-de-developpement\/male-sterile-genetiquement-modifie\/","title":{"rendered":"M\u00e2le St\u00e9rile G\u00e9n\u00e9tiquement Modifi\u00e9"},"content":{"rendered":"
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Sans impulsion g\u00e9n\u00e9tique<\/h2>\n<\/div>\n\n\n\n
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Notre processus de d\u00e9veloppement a d\u00e9but\u00e9 en 2008 avec un moustique m\u00e2le st\u00e9rile Anopheles gambiae<\/em> g\u00e9n\u00e9tiquement modifi\u00e9, qui a constitu\u00e9 la preuve du principe, dans le laboratoire d\u2019Imperial College de Londres. Pour d\u00e9velopper ce type de moustique, nous n\u2019avons pas eu recours \u00e0 la technologie d\u2019impulsion g\u00e9n\u00e9tique. Les m\u00e2les st\u00e9riles s\u2019accouplent avec les femelles de type sauvage, mais le croisement ne produit aucune prog\u00e9niture viable.<\/p>\n\n\n\n

Pour cr\u00e9er ces m\u00e2les st\u00e9riles, nous avons utilis\u00e9 un g\u00e8ne de nucl\u00e9ase qui, une fois activ\u00e9 pendant la production de sperme, fragmente le chromosome X du sperme et de l\u2019\u0153uf lors de la f\u00e9condation. Cette modification fait que les \u0153ufs ne peuvent pas \u00e9clore et aucune prog\u00e9niture n\u2019en r\u00e9sulte. La modification ne peut pas \u00eatre transmise aux g\u00e9n\u00e9rations futures de moustiques.<\/p>\n\n\n\n

Le principal objectif vis\u00e9 dans cette \u00e9tape de notre recherche \u00e9tait l\u2019acquisition de connaissances et la formation de nos \u00e9quipes et le d\u00e9veloppement des capacit\u00e9s op\u00e9rationnelles. Ce n\u2019\u00e9tait qu\u2019une \u00e9tape interm\u00e9diaire. Cela nous a permis d\u2019entamer un dialogue avec les communaut\u00e9s locales l\u00e0 o\u00f9 nous conduisons les activit\u00e9s du projet, ainsi qu\u2019avec les parties prenantes aux niveaux national et international.<\/p>\n\n\n\n

Nous avons conclu notre travail sur le moustique m\u00e2le st\u00e9rile g\u00e9n\u00e9tiquement modifi\u00e9 sans impulsion g\u00e9n\u00e9tique en 2021 et avons commenc\u00e9 notre nouvelle phase de travail sur le moustique m\u00e2le biais\u00e9 g\u00e9n\u00e9tiquement modifi\u00e9 sans impulsion g\u00e9n\u00e9tique.<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Qu\u2019est-ce qu\u2019un m\u00e2le st\u00e9rile sans impulsion g\u00e9n\u00e9tique?<\/h4>\n\n\n\n
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D\u00e9veloppement<\/h4>\n<\/div>\n\n\n\n
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En premier lieu, nous avons d\u00e9velopp\u00e9 notre souche de m\u00e2les st\u00e9riles g\u00e9n\u00e9tiquement modifi\u00e9s sans impulsion g\u00e9n\u00e9tique, en milieu confin\u00e9, dans un laboratoire d\u2019Imperial College \u00e0 Londres. Suite \u00e0 ces premi\u00e8res exp\u00e9rimentations, nous avons proc\u00e9d\u00e9 \u00e0 d\u2019autres \u00e9tudes sur les moustiques en grandes cages (jusqu\u2019\u00e0 9,2 m3<\/sup>) en collaboration avec l\u2019Universit\u00e9 de Perugia et PoloGGB en Italie. Les donn\u00e9es issues de ces exp\u00e9rimentations ont \u00e9t\u00e9 soumises aux autorit\u00e9s r\u00e9glementaires au Burkina Faso et au Mali pour demander la d\u00e9livrance de permis d\u2019importation afin de proc\u00e9der \u00e0 des travaux en milieu confin\u00e9 dans ces deux pays.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Recherche en milieu confin\u00e9 au Burkina Faso et au Mali<\/h4>\n<\/div>\n\n\n\n
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Des dossiers r\u00e9glementaires ont \u00e9t\u00e9 soumis aux autorit\u00e9s concern\u00e9es au Burkina Faso et au Mali pour demander l\u2019autorisation de proc\u00e9der \u00e0 des travaux de recherche dans les insectariums, dans le cadre d\u2019un permis d\u2019utilisation en milieu confin\u00e9. Chaque dossier a \u00e9t\u00e9 examin\u00e9 int\u00e9gralement par les autorit\u00e9s nationales concern\u00e9es dans chaque pays ; elles ont d\u00e9livr\u00e9 l\u2019autorisation d\u2019importation des moustiques modifi\u00e9s st\u00e9riles m\u00e2les, sans impulsion g\u00e9n\u00e9tique, vers les insectariums de confinement d\u2019arthropodes de niveau 2<\/a>, o\u00f9 ils devaient faire l\u2019objet d\u2019\u00e9tudes plus pouss\u00e9es. Les moustiques ont \u00e9t\u00e9 import\u00e9s en 2016 au Burkina Faso et en 2019 au Mali.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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L\u00e2cher \u00e0 petite \u00e9chelle au Burkina Faso<\/h4>\n<\/div>\n\n\n\n
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Notre \u00e9quipe de l\u2019IRSS au Burkina Faso a soumis un dossier aux autorit\u00e9s nationales de tutelle pour demander l\u2019autorisation de proc\u00e9der \u00e0 l\u2019\u00e9tape suivante de la recherche : un l\u00e2cher \u00e0 petite \u00e9chelle de moustiques m\u00e2les st\u00e9riles sans impulsion g\u00e9n\u00e9tique. La demande a \u00e9t\u00e9 approuv\u00e9e et le l\u00e2cher a eu lieu le 1er<\/sup> juillet 2019<\/a>.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Conclusion du travail sur le m\u00e2le st\u00e9rile<\/h4>\n<\/div>\n\n\n\n
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En 2021, les \u00e9quipes de Target Malaria au Burkina Faso et au Mali ont conclu leur travial sur le m\u00e2le st\u00e9rile.<\/p>\n\n\n\n

Au Mali, l\u2019\u00e9quipe a partag\u00e9 les r\u00e9sultats de deux ans d\u2019\u00e9tudes en milieu confin\u00e9<\/a> et d\u00e9truit la colonie.<\/p>\n\n\n\n

Au Burkina Faso, l\u2019\u00e9quipe travaille sur la publication des r\u00e9sultats du l\u00e2cher \u00e0 petite \u00e9chelle. L\u2019\u00e9quipe d\u2019engagement des parties prenantes a d\u00e9j\u00e0 publi\u00e9 un premier papier documentant l\u2019aspect d\u2019engagement<\/a>.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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M\u00e2le Biais\u00e9 (Sans imulsion g\u00e9n\u00e9tique)<\/a><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Sans impulsion g\u00e9n\u00e9tique Notre processus de d\u00e9veloppement a d\u00e9but\u00e9 en 2008 avec un moustique m\u00e2le st\u00e9rile Anopheles gambiae g\u00e9n\u00e9tiquement modifi\u00e9, qui a constitu\u00e9 la preuve du principe, dans le laboratoire d\u2019Imperial College de Londres. Pour d\u00e9velopper ce type de moustique, nous n\u2019avons pas eu recours \u00e0 la technologie d\u2019impulsion g\u00e9n\u00e9tique. Les m\u00e2les st\u00e9riles s\u2019accouplent avec […]<\/p>\n","protected":false},"author":31,"featured_media":4221,"parent":9686,"menu_order":69,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","featured_image_focal_point":[],"footnotes":""},"class_list":["post-5199","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nM\u00e2le St\u00e9rile G\u00e9n\u00e9tiquement Modifi\u00e9 - Target Malaria<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/targetmalaria.org\/fr\/notre-mission\/notre-processus-de-developpement\/male-sterile-genetiquement-modifie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u00e2le St\u00e9rile G\u00e9n\u00e9tiquement Modifi\u00e9 - Target Malaria\" \/>\n<meta property=\"og:description\" content=\"Sans impulsion g\u00e9n\u00e9tique Notre processus de d\u00e9veloppement a d\u00e9but\u00e9 en 2008 avec un moustique m\u00e2le st\u00e9rile Anopheles gambiae g\u00e9n\u00e9tiquement modifi\u00e9, qui a constitu\u00e9 la preuve du principe, dans le laboratoire d\u2019Imperial College de Londres. 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